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Daniel Catenacci YouTube Videos for Hope for Stomach Cancer

Introduction to Dr. Dan's Videos on YouTube Hope for Stomach Cancer

Full series of videos on the Hope For Stomach cancer YouTube Channel


This introductory set of videos below provide the background, epidemiology, and basic biologic understanding that set the stage and foundation for all the diagnosis and treatment videos.


This is an introduction to the Video Library of Hope for Stomach Cancer on gastroesophageal cancers (GECs), created by Dr. Dan Catenacci. The Video Library is intended for patients and caregivers, as well as students, trainees, and clinical providers of gastroesophageal cancers to better understand the disease and its treatments, in order to help patients through their difficult journey. Having experienced gastric cancer in his family from a young age, Dr. Dan has the goal of helping those having similar experiences. Indeed, Dr. Dan never got to know his grandfather who passed away from gastric cancer at the age of 50 before Dr. Dan was born. This, along with others in his family being diagnosed with gastric cancer, was a calling for Dr. Dan to pursue a vocation in Medicine and Oncology, in order to improve the outcomes for patients diagnosed with gastroesophageal and other gastrointestinal cancers.


In this introductory video, Dr. Dan takes you through the basic understanding of cancer, and discusses the 3 main subsets of gastroesophageal cancer, including gastric non-cardia cancer, esophagogastric adenocarcinoma, and esophageal squamous cell cancer.


In this video, Dr. Dan discusses the incidence of gastroesophageal cancers globally and within the United States. He also explains the risk factors and known causes of the three subtypes of gastroesophageal cancer.


In this video, Dr. Dan explains why and how cancer occurs, going back to basic biology to understand the fundamentals of DNA, RNA, and protein, and that cancer is ultimately a problem with an altered DNA blueprint within the cell. Dr. Dan discusses what causes DNA changes including inherited (germline) changes and acquired (somatic) changes, including random changes as well as lifestyle and exposures to various carcinogens in the environment. An understanding of this background biology will help to understand the nuances of molecular profiling of the cancer and ensuing targeted and immunotherapies in later videos.


In this video, Dr. Dan explains the difference between a germline (inherited) versus somatic (acquired) genetic subset of GEC called mismatch repair deficiency (dMMR), and consequent high microsatellite instability (MSI-High). dMMR/MSI-H occurs in about 3% of stage IV GEC and 7-8% of locally advanced GEC, the majority of which are not germline, but somatic.


In this video, Dr. Dan explains the difference between a germline and somatic genetic subset of GEC having CDH1 gene mutation and consequent e-cadherin loss/dysfunction, and the link of this mutation with diffuse-type signet ring gastric cancer. CDH1 mutation is common in diffuse-type gastric cancer, the majority of which are somatic, whereas less than 5% are estimated to be germline.


In this video, Dr. Dan discusses early onset of GEC at young ages (less than 40 or 50 years old), comparing and contrasting the incidence, biology, and prognosis of young onset GEC to the more common later onset GEC.


Daniel Catenacci YouTube Videos for Hope for Stomach Cancer

Daniel Catenacci GI Medical Oncologist
Daniel Catenacci MD


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